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DNA Swabbing vs. Blood Samples in DNA Testing

Sep 13, 2018 | Paternity

Swabs vs. Blood Samples in DNA Testing

The two most popular methods for collecting DNA in labs are blood samples and cheek swabs. The DNA testing results from extracting DNA-rich cells via swabs or blood samples are exactly the same, only there are differences in how the two samples are processed. Both have different advantages. Neither has been proven to be more accurate than the other, so it ultimately depends on your preference or the lab’s ability to provide. The convenience and comfort of a cheek swab (buccal swab) makes it the clear favorite for DNA paternity testing! Let’s explore how these two methods work.

Swabs vs. Blood Samples for DNA Collection

Cheek Swabs for DNA Collection

People contributing DNA samples for paternity testing or immigration testing usually follow the normal procedures for DNA testing centers around the country, which generally use cheek swabs. There are actually several different methods for collecting DNA from your mouth area:

  1. Dry procedures: This requires the insertion of swabs that scrape tissue from the inside of your cheeks. This is what is most often used for paternity tests
  2. Wet procedure: This usually involves swishing a liquid around in your mouth and spitting the specimen into a collecting device. During this process, bacteria can also be released into your sample. This method can be used for some medical tests
  3. Noninvasive procedure: With some procedures, you spit out the collecting solution and another is added to eliminate bacteria and help preserve the integrity of the sample. This is the type of sample required for some ancestry tests

Depending on which procedure is used at the DNA-testing facility, a collection specialist verifies the person’s identity, gets a signed consent form, swabs the inside of the patient’s cheek, and then safely packs the DNA specimen into its safe storage.

IMPORTANT: People often confuse collecting DNA via cheek cells and collecting DNA via spit. The two are NOT interchangeable processes. If you are doing a paternity test, do not spit on the swabs. Follow directions in the kit and be sure to scrape the insides of the cheeks only. Rubbing the gums may results in collecting excess saliva. If the swabs seem too wet to put in the paper collection envelopes, your instincts are probably correct. Take a few minutes to air-dry the swabs as much as possible by holding them up and waving them in the air prior to putting them in the envelopes.

 


LEARN HOW TO PREVENT SAMPLE CONTAMINATION >


 

Pros and Cons for Swab DNA Samples
Swab collections have a number of advantages:

  • No needle is used and no puncture of the skin is necessary
  • It’s a quick, non-invasive procedure, with no pain involved
  • The DNA collected is good indefinitely after collection if stored properly
  • Scientists prefer the easier extraction process from a testing point of view
  • Patients usually are more relaxed and less stressed about the DNA collection process
  • They’re relatively affordable to collect

On the other side, the main cons ascribed to swabs are:


SEE INSTRUCTIONS FOR SWABBING CHEEKS


Blood Samples for DNA Testing

The process of collecting blood works basically the same as with cheek swabs, but isn’t quite as easy—a needle is inserted to draw your blood. Some people are squeamish with needles, so there is always that initial testing apprehension. Although the majority of tests performed require only a cheek-swab sample, there are a few instances where a blood sample is required:

  1. Non-invasive prenatal paternity testing: A paternity test between an alleged father and an unborn child can be performed anytime after the 8th week of pregnancy. For this test, the alleged father’s DNA is collected via cheek swab, but the mother must have blood drawn. Fetal DNA is present in the mother’s bloodstream, and the baby’s DNA profile can be isolated from the mother’s, using that blood sample
  2. Newborn testing: Hospitals across the USA prick a baby’s heel and collect a blood sample for the purposes of newborn genetic screening

Pros and Cons for Blood DNA Samples
Taking blood samples for DNA testing do have a few pros of their own, including:

  • Clean blood in proper tubes minimizes chances of contamination
  • Fast and quick procedure
  • Blood samples are visible

There are quite a few cons too:

  • If a person has recently had a blood transfusion before a sample is drawn, the results could show two separate DNA profiles
  • Needles puncture the skin—patients will feel some degree of pain
  • Multiple attempts may be required to insert the needle into smaller, thinner blood veins
  • Possible screaming and crying if children are required to get a DNA blood sample
  • Blood samples are fast to collect, though not as quick as swab samples

Which Would You Use?

Both of these tests have their advantages and disadvantages. The bottom line is that you get highly reliable paternity test results from both. No matter which method is used , a DNA sample from your mouth is just as accurate as one from your blood sample when processed by an experienced testing laboratory.

Call us at 800-929-0847: We’re here to help.

Do you have questions or comments about DNA from cheek swabs vs. DNA from blood samples? Share in the comments and we’ll answer.

40 Comments

  1. Kameisha

    My child has a chromosome translocations and she have had a blood transfusion when she was 6 months of age could that affect the outcome of a paternity test

    Reply
    • DDC

      Hi, Kameisha. No, that shouldn’t be a problem, but it would be wise to notify the lab ahead of testing.

      Reply
      • Tameka

        My daughter and her baby father did a home kit, he has sickle cell, and receives monthly treatments. The test revealed baby is not his. She says it was no other man. Could his blood transfusion and stem cells donors cause this to happen?

        Reply
        • DDC

          Hi, Tameka. The stem-cell treatments especially can skew results, yes.

          Reply
  2. Crystal

    Hi my daughter blood type is A+ both me and her father are. O+ is he not the father based on that ?

    Reply
    • DDC

      Two parents with type O blood would only produce a child with type O.

      Reply
      • DJ

        Does the blood test coast more than the swab test

        Reply
        • DDC

          Hi, DJ. If the test can be performed using a swab sample instead of a blood sample then yes, it costs more.

          Reply
    • Crystal

      I was with two men around the same time I got pregnant. One guy tested two times….at home and at a lab, and the results were both negative. The other guy just tested, but he also works for the military. Could a blood test rule out who could most likely be the father of my son.

      Reply
      • DDC

        When it comes to accuracy, there is no difference between a blood sample and a swab sample.

        Reply
  3. Elsamarie

    Non-invasive Prenatal Paternity testing

    Reply
  4. Gloria

    can blood taken from the finger tips of a mother be used as sample for prenatal paternity DNA test to give an accurate results?

    Reply
    • DDC

      Hi, Gloria. No, that is not enough blood. Blood must be drawn by a professional.

      Reply
  5. Ashley

    Can a Dna test from months ago be used for a recent dna test for this month if it was the mouth swab

    Reply
    • DDC

      Hi, Ashley. I cannot speak for other labs, but DDC requires new DNA samples if the test was months ago.

      Reply
  6. Howard

    Can a sample of my saliva for a Coronavirus test be used for DNA testing?

    Reply
    • DDC

      Hi, Howard. We require fresh samples for all testing. You didn’t specify what type of DNA test you’re interested in, but keep in mind most of our tests use DNA collected via cheek swabs.

      Reply
  7. Artra

    Hi, I just received results for my son it came back 0 … is there a possibility the test was old, because I was informed it was, or could it have been tampered with, or could I have done it incorrectly … please advised looking to do the test again.

    Reply
    • DDC

      Hi, Artra. If you tested with DDC, you can be sure the results are correct for the samples we were provided to test. If you witnessed the swabbing of all participants and mailed the samples off yourself, then you can have some confidence they weren’t tampered with prior to arriving at the lab.

      Reply
  8. Breonna

    Can inherited disorders from one parent effect the results?

    Reply
    • DDC

      Hi, Breonna. Inherited disorders do not affect paternity testing results, since only non-coding DNA is used for paternity tests.

      Reply
    • Kim

      Can you get a fake dna test to say what you want the results to be provided you took a real one. And why can I reveal the results online with the reference number that I was provided?

      Reply
      • DDC

        Hi, Kim. Anyone can fake any kind of document. And I’m sorry, but I’m not clear on your second question. Are you not able to access your results online? If not, contact us for assistance.

        Reply
  9. Quan

    Me and my daughter took a Swab DNA test and results came back 0. My wife swear she had sex with the other guy one time in December but baby was was born in July. Is there anyway the results can be wrong ? Baby girl is only 2 month and wife wants a blood test done. She swear the test in inaccurate.

    Reply
    • DDC

      Hi, Quan. You don’t mention if you tested with an accredited lab, however, if the exact same DNA is submitted for the second test as was submitted for the first, then you can expect the results to be exactly the same again. Blood testing is no more accurate than swab testing…it’s all the same DNA. If the test was done through an accredited lab, you can be sure the report is accurate for the samples provided for testing.

      Reply
    • Ash

      Hey Quan did you get a blood test done I’m going through the same thing with my son

      Reply
  10. Lauren

    Does the mouth swab DNA show the exact same numbers every time. ? For instance if I did a dna test with ddc then did a dna test from another site will the swab numbers be the same ?

    Reply
    • DDC

      Hi, Lauren. Yes, most accredited lab use the CODIS markers used by the FBI, at a minimum. Some, like DDC, use more.

      Reply
  11. Larry

    Can a DNA test via blood sample help determine if I am a chimera?

    Reply
    • DDC

      It can under specific circumstances.

      Reply
  12. breanna

    will i as the mother get the results back before the father does?

    Reply
    • DDC

      Hi, Breanna. Online access is provided to the person who ordered the test and whose email address we have on file.

      Reply
  13. Naomi P

    My alleged father and I took a swab DNA test. Before we took the test i drank coffee on my way to the lab which would be 15 minutes prior to test. My alleges father smoked 10 minutes prior. So we took the swab dna and I came back 0%. So is this still considered accurate.

    Reply
    • DDC

      Hi, Naomi. Drinking or smoking prior to swabbing can’t change the DNA itself: the only thing it can do is possibly contaminate the samples, making DNA extraction impossible. However, since you were issued results, drinking and smoking weren’t issues and you can trust your results.

      Reply
  14. Karen

    If a blood test was drawn and sent to a Police Dept Sensitive Crime Division where dried blood from the potential father was used from a liquid blood standard and swabs of the baby and mother where using the PCR and typed for short tandem repeat (STR) loci using the Applied Biosystems AmpFISTR Profiler Plus and AmpGISTR kits..STR profiles were developed for the amplified DNA.
    The mother and baby were consistent to an STR profile and so was the father concluding heim as a possible biological father. It stated that the potential father STR pfofile is at least 4.2 million times more liely that he is the biological father than some other unknown unrelated individual.
    The victim (mother) in this case also had sex with the defendant’s son and cousin around the same time. Should they too be tested?

    Reply
    • DDC

      Hi, Karen. Seeing as the defendant’s son is another possible father and is a close relation to the man tested, he should also be tested, yes.

      Reply
  15. Kristin

    Im 17wks pregnant n want to get a paternity test. My blood type is B+ what should my unborn baby be and what dad blood could be to be his. He wont tell me.

    Reply
    • DDC

      Hi, Kristin. Although the mother’s sample for non-invasive prenatal paternity test is blood, we don’t actually test for blood type. We test the free-floating fetal DNA in the blood to the DNA profile for the possible father. If you want to learn more, please call our experts directly at 800-929-0847 (M-F, 8 AM to 8 PM Eastern).

      Reply
  16. Nicole

    I took a prenatals non-invasive DNA test with my daughters dad while I was pregnant and the results came back 99.99 percent. Sense she looks white. He wants to take another one. He already took an at home kit DNA test from Walgreens and we just went to a lab as well and had a professional do it. Should the results be the same . Haven’t gotten results back but I will definitely update.

    Reply
    • DDC

      Hi, Nicole. If the same people’s DNA are submitted, then all results should be exactly the same. P.S. I would be wary of making any assessments that a baby “looks white.” Physical characteristics are very subjective and only DNA can determine precisely who the father is.

      Reply

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