Swabs vs. Blood Samples in DNA Paternity Testing

Sep 13, 2018 | Blog, DNA test

Swabs vs. Blood Samples in DNA Testing

The two most popular methods for collecting DNA in labs are blood samples and cheek swabs. The DNA testing results from extracting DNA-rich cells via swabs or blood samples are exactly the same, only there are differences in how the two samples are processed. Both have different advantages. Neither has been proven to be more accurate than the other, so it ultimately depends on your preference or the lab’s ability to provide. The convenience and comfort of a cheek swab (buccal swab) makes it the clear favorite for DNA paternity testing! Let’s explore how these two methods work.

Swabs vs. Blood Samples for DNA Collection

Cheek Swabs for DNA Collection

People contributing DNA samples for paternity testing or immigration testing usually follow the normal procedures for DNA testing centers around the country, which generally use cheek swabs. There are actually several different methods for collecting DNA from your mouth area:

  1. Dry procedures: This requires the insertion of swabs that scrape tissue from the inside of your cheeks. This is what is most often used for paternity tests
  2. Wet procedure: This usually involves swishing a liquid around in your mouth and spitting the specimen into a collecting device. During this process, bacteria can also be released into your sample. This method can be used for some medical tests
  3. Noninvasive procedure: With some procedures, you spit out the collecting solution and another is added to eliminate bacteria and help preserve the integrity of the sample. This is the type of sample required for some ancestry tests

Depending on which procedure is used at the DNA-testing facility, a collection specialist verifies the person’s identity, gets a signed consent form, swabs the inside of the patient’s cheek, and then safely packs the DNA specimen into its safe storage.

IMPORTANT: People often confuse collecting DNA via cheek cells and collecting DNA via spit. The two are NOT interchangeable processes. If you are doing a paternity test, do not spit on the swabs. Follow directions in the kit and be sure to scrape the insides of the cheeks only. Rubbing the gums may results in collecting excess saliva. If the swabs seem too wet to put in the paper collection envelopes, your instincts are probably correct. Take a few minutes to air-dry the swabs as much as possible by holding them up and waving them in the air prior to putting them in the envelopes.




Pros and Cons for Swab DNA Samples
Swab collections have a number of advantages:

  • No needle is used and no puncture of the skin is necessary
  • It’s a quick, non-invasive procedure, with no pain involved
  • The DNA collected is good indefinitely after collection if stored properly
  • Scientists prefer the easier extraction process from a testing point of view
  • Patients usually are more relaxed and less stressed about the DNA collection process
  • They’re relatively affordable to collect

On the other side, the main cons ascribed to swabs are:

Blood Samples for DNA Testing

The process of collecting blood works basically the same as with cheek swabs, but isn’t quite as easy—a needle is inserted to draw your blood. Some people are squeamish with needles, so there is always that initial testing apprehension. Although the majority of tests performed require only a cheek-swab sample, there are a few instances where a blood sample is required:

  1. Non-invasive prenatal paternity testing: A paternity test between an alleged father and an unborn child can be performed anytime after the 8th week of pregnancy. For this test, the alleged father’s DNA is collected via cheek swab, but the mother must have blood drawn. Fetal DNA is present in the mother’s bloodstream, and the baby’s DNA profile can be isolated from the mother’s, using that blood sample
  2. Newborn testing: Hospitals across the USA prick a baby’s heel and collect a blood sample for the purposes of newborn genetic screening

Pros and Cons for Blood DNA Samples
Taking blood samples for DNA testing do have a few pros of their own, including:

  • Clean blood in proper tubes minimizes chances of contamination
  • Fast and quick procedure
  • Blood samples are visible

There are quite a few cons too:

  • If a person has recently had a blood transfusion before a sample is drawn, the results could show two separate DNA profiles
  • Needles puncture the skin—patients will feel some degree of pain
  • Multiple attempts may be required to insert the needle into smaller, thinner blood veins
  • Possible screaming and crying if children are required to get a DNA blood sample
  • Blood samples are fast to collect, though not as quick as swab samples

Which Would You Use?

Both of these tests have their advantages and disadvantages. The bottom line is that you get highly reliable paternity test results from both. No matter which method is used , a DNA sample from your mouth is just as accurate as one from your blood sample when processed by an experienced testing laboratory.

Call us at 800-929-0847: We’re here to help.

Do you have questions or comments about DNA from cheek swabs vs. DNA from blood samples? Share in the comments and we’ll answer.


  1. Kameisha

    My child has a chromosome translocations and she have had a blood transfusion when she was 6 months of age could that affect the outcome of a paternity test

    • DDC

      Hi, Kameisha. No, that shouldn’t be a problem, but it would be wise to notify the lab ahead of testing.

  2. Crystal

    Hi my daughter blood type is A+ both me and her father are. O+ is he not the father based on that ?

    • DDC

      Two parents with type O blood would only produce a child with type O.

  3. Elsamarie

    Non-invasive Prenatal Paternity testing

  4. Gloria

    can blood taken from the finger tips of a mother be used as sample for prenatal paternity DNA test to give an accurate results?

    • DDC

      Hi, Gloria. No, that is not enough blood. Blood must be drawn by a professional.

  5. Ashley

    Can a Dna test from months ago be used for a recent dna test for this month if it was the mouth swab

    • DDC

      Hi, Ashley. I cannot speak for other labs, but DDC requires new DNA samples if the test was months ago.


Submit a Comment

Your email address will not be published. Required fields are marked *

Everything You Need to Know about the Latest Baby Gender Prediction Test

Everything You Need to Know about the Latest Baby Gender Prediction Test

   Expectant parents often want to know at which week they can find out their baby’s gender.Throwing a gender reveal party, sharing the news with family and friends, and decorating the nursery are a few reasons why parents-to-be want to know their baby’s gender. A...

Holistic Prenatal Care: How Does a Gender DNA Test Affect Pregnancy?

Holistic Prenatal Care: How Does a Gender DNA Test Affect Pregnancy?

   A 2017 Swedish study found that 95.8% of women discussed gender with their partner before the ultrasound scan, and 57% of couples wanted to find out the gender of their baby. Parents initiated this discussion with midwives 46% of the time, while midwives initiated...

Is There Such a Thing as an Infidelity Gene?

Is There Such a Thing as an Infidelity Gene?

It’s only natural for someone who has been cheated on to ask why their partner was unfaithful. A handful of studies have suggested that genes and hormones may predispose some men and women to infidelity. So that begs the question: Is cheating genetic? Here’s a look at...

Reach Us

Have questions or need assistance? Contact our team.

DNA Technology Park
1 DDC Way
Fairfield, OH 45014

Leave A Message