Genotyping Services

Superior genotyping services for academic and pharmaceutical research needs.

Determining the Differences

DNA Diagnostics Center (DDC) offers a variety of high-quality genotyping services that meet the needs of academic and pharmaceutical customers. Our advanced laboratory delivers robust, reproducible results that are cost effective and reliable.

SNP Analysis

DDC designs tests for single or multiplexed genotype assays utilizing Real Time, Fluidigm, and Affymetrix Gene Tital platforms. The laboratory is CAP accredited to genotype with the Precision Medicine Research Array (PMRA).

Case Study: A major U.S. research center elected to use the PMRA from Aﬀymetrix given its aﬀordability and breadth of markers. The lead researcher was looking for a reliable outsourced laboratory partner with validated PMRA experience and the Gene Titan instrument. DDC was chosen over the researcher’s in-house lab to do both the DNA sample extraction and SNP analysis using PMRA given our aﬀordable pricing, fast turn-around times and reliable results.

Next-Gen Sequencing

DDC provides testing in rapid and high throughput modes using the Illumina HiSeq platforms. The laboratory has multiple machines to accommodate high volumes and redundant backup.

Case Study: DDC works with one of the publicly traded market leaders in non-invasive prenatal testing. Our laboratory was selected to be the global partner lab for non-invasive prenatal paternity tests using NGS and a proprietary algorithm.

Precision Ethnicity™

DDC uses a sophisticated, academically rigorous algorithm that characterizes ethnicity into 41 gene pools and leverages over 1,000 reference populations.

Using client SNP or NGS data from submitted ﬁles, DDC provides precision ethnicity to support patient recruitment and clinical trials. Researchers either use DDC’s custom Precision Ethnicity™ array with Ancestry Informative Markers (AIM) or a commercial array such as the Precision Medicine Research Array (PMRA) as the data source. Adding this tool to the research protocol helps validate patient self-reported information and is shown to reduce genomic interference in clinical trial cohorts.

A world-renowned medical group interested in following cancer patients’ prognosis found that African ancestry resulted in a worse outcome. Using DDC’s Precision Ethnicity™ algorithm, they were able to subdivide their patients into diﬀerence geographic populations within Africa and evaluate the correlation with treatment response.