Human Embryo has Three Parents

Nov 2, 2012 | DNA test, Paternity, Paternity Test

A team of scientists reported in the October 24th issue of Nature the successful creation of human embryos using eggs that had their nuclear DNA replaced by with the nucleus from another egg. The eggs were then fertilized in vitro to produce embryos that had genetic material from three sources: the “host” egg containing mitochondrial DNA (mtDNA), the donor egg (contributing the maternal half of the nuclear DNA), and the sperm (contributing the paternal half of the embryo’s nuclear DNA).
In humans, nuclear DNA is comprised by the 46 chromosomes found in the nucleus, with 23 inherited from the father and 23 inherited from the mother. This is the DNA that dictates most of body’s functions and characteristics, essentially establishing a person’s unique identity, and it’s also what DDC analyzes in a parentage test.
Mitochondrial DNA, on the other hand, is found outside the nucleus, in the organelles that generate energy for the cell. During fertilization, only the nuclear DNA from the sperm enters an egg cell, which means that the resulting embryo contains mtDNA only from the mother. In this way, mtDNA is passed from the mother to all her children, and the female children pass their mtDNA to their offspring, throughout the generations, relatively unchanged. This inheritance pattern is what allows those interested in ancestry research to trace maternal lineages through mtDNA testing.
The ultimate goal of the study is to allow couples with a family history of mitochondrial diseases to bear children who are free of the disease. That is, couples might choose to use a host egg with healthy mtDNA and inject it with the mother’s nuclear DNA as part of an in vitro fertility procedure. Each year, 1,000 to 4,000 children in the United states are born with a mitochondrial disease ( The scientific team that produced the study is awaiting FDA approval on clinical use of the technology (in the study, the embryos were developed in vitro to blastocyst stage and then used to make stem cells).
For more information on this study, visit the Nature News article.
What are your thoughts? Would you want to know if your child had the potential for mitochondrial diseases?

Top 5 Reasons to Get a Home Paternity Test

Top 5 Reasons to Get a Home Paternity Test

Choosing to take a paternity test for either yourself or your child can be an emotionally challenging experience, but there are many benefits to taking this step. Call Now: Article Contents: 1. Peace of Mind 2. Convenience 3. Understanding Medical History...

How Much Does a Paternity Test Cost?

How Much Does a Paternity Test Cost?

As one of the world’s most highly accredited and trusted DNA testing laboratories, people ask us, “How much does a paternity test cost?” every day. With the explosion of DNA testing providers in recent years, it’s easy for people who need a paternity test to get confused about which one they should choose. 

Can I Get a Paternity Test While Pregnant?

Can I Get a Paternity Test While Pregnant?

Doubts regarding who the father of your baby is can be extremely challenging to navigate. Thankfully, you can get the answers you need before the baby is born with a non-invasive prenatal paternity (NIPP) test.

Reach Us

Have questions or need assistance? Contact our team.

DNA Technology Park
1 DDC Way
Fairfield, OH 45014

Leave A Message