Blog

DNA Diagnostics Center Discovers Rare Chimera Paternity Case

Oct 27, 2015 | DNA science, DNA test, Paternity, Paternity Test

Human fetus
DNA Diagnostics Center (DDC) was recently involved with a unique paternity case where the alleged father proved to be a chimera. A chimera is an individual whose tissues contain cells from a sibling due to a mixing of cells during gestation. Physical clues are often present, in the form of two-toned, patchy skin tones.
If two different eggs are fertilized with different sperm, and if each matures, they will ultimately produce twins.  In a chimera, early in gestation the cells from one of the twins fuses with the growing cells of the other twin resulting in only one viable embryo going forward. This embryo contains cells from both twins in a single individual. Not all tissues will be chimeric. Those tissues that are chimeric will contain DNA from both of the twins while those tissues that are not chimeric will contain DNA from only one of the twins.
The occurrence of chimerism is difficult to determine since it does not lead to adverse medical conditions. It is likely that all of us have DNA in some of our cells that differ by a few DNA letters in the 3 billion that are present in each cell. It is only when a sufficient number of cells in the germ line tissue (those that make sperm or eggs) are chimeric that paternity or maternity results can be affected. DDC considers chimerism in testing and requests appropriate tissue samples to clarify those cases.
The chimera alleged father presented the first chimera case involving germ line tissue seen by DDC in its 20 years. The cells in the sperm producing tissue of the alleged father were chimeric while the cells from the inside of his cheek, which are typically used for paternity testing, were not chimeric. As a result, the person was excluded as the biological father of a child when his buccal cell DNA was used and included when his sperm cell DNA was used.
Although chimerism in paternity is rare, DDC does incorporate chimera detection in its paternity testing process. To learn more, see the DDC website (dnacenter.com) for the posters on this chimera paternity case, co-authored by Dr. Michael Baird, Chief Science Officer at DDC, and presented this year (2015) at the American Society of Human Genetics Annual Meeting in Baltimore and at the International Symposium on Human Identification held in Dallas.
For media inquiries, please contact us at press@dnacenter.com

0 Comments

Debunking Paternity Test Myths

Debunking Paternity Test Myths

Finding out the identity of a baby’s father provides certainty, allowing the mother and child to move on with their lives. Moreover, getting a paternity test may be necessary for important legal reasons. Despite DNA paternity testing being around for many years,...

Paternity Test Privacy: Should I be Concerned?

Paternity Test Privacy: Should I be Concerned?

Paternity information is ultrasensitive, so we understand if you have concerns about DNA testing privacy when ordering a test. It’s natural to want to control access to highly sensitive personal information, and moreover, taking a test can be stressful since results...

10 Reasons Someone Would Want a Sole Custody Agreement

10 Reasons Someone Would Want a Sole Custody Agreement

IMPORTANT: This article gives general information. Keep in mind  specific processes and laws can vary state by state and we are not providing legal advice. If you have further questions, we strongly suggest you contact a family-law attorney. When Britney Spears...

Paternity Test While Pregnant is Possible

Paternity Test While Pregnant is Possible

   A High-Tech Prenatal Option for Establishing Paternity In August 2011, DDC unveiled the most innovative test of its kind in the last decade: the first non-invasive prenatal paternity test using SNP (single-nucleotide polymorphism) Microarray Technology, which...

Reach Us

Have questions or need assistance? Contact our team.

DNA Technology Park
1 DDC Way
Fairfield, OH 45014

Leave A Message